P-Shot for Peyronie’s Disease: Does PRP Therapy Help Penile Curvature?
✅Medically reviewed | Updated September 2026
A penis that bends during erection can reshape intimacy, confidence and long-term health decisions. Peyronie’s disease affects roughly 1 in 16 men, and urologists suspect under-reporting. Meanwhile, private clinics increasingly promote platelet-rich plasma (PRP) injections as a regenerative solution. The P-Shot for Peyronie’s disease draws interest because it uses the patient’s own blood and avoids surgery. However, online summaries often promise more than the data deliver.
This article examines what the research actually shows. In addition, it reviews trial data from Morocco, Italy, France and the United States. It also compares NHS and NICE material with European Association of Urology (EAU) and American Urological Association (AUA) guidance. Overall, each section separates established facts from early findings.
PRP may reduce curvature modestly in some men, but no guideline recommends it as standard care. Readers will find realistic figures, safety data, study limitations and a comparison with other penile curvature treatment options.
What Is Peyronie’s Disease?
Peyronie’s disease develops when fibrous scar tissue, called plaque, forms in the tunica albuginea. This fibrous layer surrounds the erectile chambers of the penis. The plaque lacks elasticity. As a result, the penis bends, narrows or shortens during erection.
The NHS states that the condition mainly affects men over 40, although younger men can develop it. Mild cases may need no treatment. However, pain, depression or difficulty with sex often justify medical help. A pronounced curve or a painful erection warrants a GP appointment.
Prevalence and Causes
NHS Hertfordshire and West Essex Integrated Care Board (ICB) policy estimates that about 6% of men have the condition. The same policy notes that the true figure may reach 10%. The cause remains unknown. Researchers favour a model of repeated micro-injury followed by an exaggerated fibrotic response. Inherited predisposition may also contribute.
Acute and Chronic Phases
Clinicians divide the disease into two phases. According to NHS Lothian, the acute phase lasts three to six months. ICB policy allows up to 12 months. Inflammation, pain and changing curvature characterise this stage. The chronic phase begins when pain settles and curvature stops changing. NHS Lothian reports that curvature stabilises in about 70% of men. It worsens again in 20% and improves in about 10%.
For this reason, phase matters for treatment choice. NHS Lothian guidance recommends referral to secondary care once the chronic phase begins. Surgical options come into consideration only after that point.
How the P-Shot Works
The P-Shot, also called the Priapus Shot, is a branded term for PRP injection into penile tissue. First, a clinician draws a small blood sample from the arm. A centrifuge then spins the sample and concentrates the platelets. Finally, after local anaesthetic, the clinician injects the concentrate.
Technique differs between conditions. Standard P-Shot protocols for erectile function target the erectile chambers. In contrast, Peyronie’s studies inject PRP directly into or around the plaque. Therefore, the P-Shot for Peyronie’s disease uses a different injection strategy from the P-Shot for erectile dysfunction.
PRP Tissue Repair: The Biological Rationale
Platelets store growth factors, including platelet-derived growth factor and vascular endothelial growth factor. These factors support PRP tissue repair by stimulating cell growth, new blood vessels and collagen remodelling. Furthermore, PRP already features in orthopaedic, wound-healing and dermatological practice.
However, Peyronie’s plaque reflects dysregulated fibroblast activity and excess collagen. Transforming growth factor beta drives part of that process, and PRP also contains it. Consequently, the net effect of PRP on plaque biology remains unproven. A plausible mechanism does not prove a clinical benefit.
What Does the Evidence Say About the P-Shot for Peyronie’s Disease?
Research on PRP for Peyronie’s has expanded in recent years, yet most studies remain small. Randomised data are only now emerging.
Early Cohort Studies
A Moroccan prospective study enrolled 65 men with curvature between 25° and 45°. Participants received an average of 6.1 PRP injections. Curvature improved by about 17° in both severity groups. The share of men with painful intercourse fell from 70.7% to 34.25%. However, the study had no control group. Therefore, placebo effects and natural improvement could explain part of the change.
An Italian cohort of 72 men received three injections two weeks apart. Median curvature fell from 50° to 40°. Similarly, median plaque size fell from 11.1 mm to 8.2 mm. A French pilot study of 17 men reported significant improvement in Peyronie’s Disease Questionnaire scores at three months. In addition, that study recorded no side effects.
Findings in Chronic Peyronie’s Disease
A 2026 Italian retrospective study offers a more cautious picture. Researchers treated 36 men with stable disease using three weekly injections. Mean curvature fell from 30.5° to 24.2°, a change of 6.3°. Only 25% of men achieved a reduction of 10° or more, a threshold often regarded as clinically relevant. Furthermore, erectile function scores rose by 1.1 points, which did not reach statistical significance. The authors concluded that PRP should stay investigational until randomised trials report.
Randomised Trial Data
The most rigorous data reviewed here come from a University of Miami trial. Researchers randomised 41 men to PRP or saline injections and crossed the groups after three months. An interim analysis of 28 men found no adverse events. At six months, the group that received PRP first reached a median curvature of 25° (p = 0.047). In contrast, the group that received saline first showed no significant change (p = 0.490). The authors described a delayed effect and warned that the small sample limits conclusions. The published report covers interim data only.
Systematic Review Findings
A 2024 World Journal of Urology systematic review searched for PRP studies in erectile dysfunction and Peyronie’s disease. It included 17 studies. Four used randomised designs. Together, the studies covered 1,099 patients. Most showed small to moderate benefits. Side effects stayed mild and transient, and no major adverse events emerged. Across the literature, benefits look small to moderate, and large randomised confirmation is still missing.
Guideline Position: NHS, NICE, EAU and AUA
No UK guideline recommends the P-Shot for Peyronie’s disease as a penile curvature treatment. ICB policy states that good evidence and UK guidance on conservative management remain lacking. The policy points clinicians to EAU guidance instead. The same policy declines to fund shockwave therapy because of inadequate evidence.
NICE holds interventional procedures guidance on shockwave therapy for Peyronie’s disease, dating from 2003. That guidance also describes treatments as relieving symptoms rather than curing the disease. However, the NICE material reviewed for this article contains no recommendation on PRP.
Specialist societies take a firmer line. A 2024 narrative review reports that the AUA and EAU classify PRP and stem cell therapy as experimental. This applies to Peyronie’s disease. Similarly, a 2025 Korean consensus statement reaches the same conclusion. The AUA also treats PRP as experimental for erectile dysfunction. In guideline terms, PRP remains an experimental penile curvature treatment.
Who Might Consider PRP for Peyronie’s?
Published studies mostly enrolled men with moderate curvature. For example, the Moroccan cohort included angles of 25° to 45°. The Italian cohorts reported baseline averages between about 30° and 50°. Data for severe curvature appear sparse. The three larger cohorts described above also enrolled men with stable disease. Therefore, evidence for the acute phase remains limited.
Erectile dysfunction often coexists with Peyronie’s disease. Separate assessment matters because erectile difficulty can block intercourse independently of curvature. Sound practice includes the following steps before any injection:
- A confirmed diagnosis, based on examination and, where indicated, ultrasound.
- Objective curvature measurement, ideally by goniometer or standardised photographs.
- Separate assessment of coexisting erectile dysfunction.
- Screening for bleeding disorders and anticoagulant use.
- A frank discussion of experimental status and realistic outcomes.
Men with severe curvature that prevents intercourse should seek a urology opinion about surgical options. NHS Lothian lists inability to achieve penetrative intercourse as a referral indication.
Realistic Outcomes and Study Limitations
Cohort data show average curvature reductions between about 6° and 17°. Individual response varies widely. Measurement methods also differ. One reviewed study relied on patient-taken photographs and lacked validated questionnaires. In the Italian retrospective study, only one in four men reached a 10° reduction. ICB policy states that treatment cannot completely reverse the changes. Complete straightening is not a realistic expectation.
Why Current Studies Need Caution
Several limitations weaken the current evidence:
- Most studies lack a control group, so placebo effects and natural fluctuation remain possible.
- Sample sizes stay small, often below 100 men.
- Injection numbers and intervals differ, from three injections to about six.
- Follow-up periods range from four weeks to six months.
- PRP preparation systems vary in platelet concentration.
Because of these gaps, no study proves lasting benefit. Larger randomised trials with standard protocols and longer follow-up remain essential.
Comparing Penile Curvature Treatment Options
The P-Shot for Peyronie’s disease forms one of several penile curvature treatment routes. Each route suits a different stage and severity.
Observation and Conservative Care
The NHS advises that mild symptoms may need no treatment. However, ICB policy notes that good evidence for conservative measures remains lacking. Therefore, expectations should stay modest for oral and device-based approaches.
Collagenase Injections
Collagenase (Xiapex) once served as the main injectable option. ICB policy confirms that the manufacturer withdrew it from the European market. Consequently, the UK no longer has supply. French researchers link rising interest in PRP partly to that withdrawal.
Shockwave Therapy
NICE published guidance on shockwave therapy in 2003. According to a 2024 review, the AUA and EAU support shockwave therapy for pain control only. Local NHS policy does not fund it. Hence, shockwave therapy offers limited help for curvature.
Surgery
Surgery suits men with stable curvature that blocks intercourse. Surgery cannot usually restore the penis to its original shape, according to the NHS. Options include plication, grafting and prosthesis implantation. Surgery currently remains the most established route for severe, stable curvature.
Safety, Side Effects and Costs
Reported Safety Profile
PRP uses the patient’s own blood, so allergic reaction is unlikely. Overall, reported adverse events remain mild. Safety data for the P-Shot for Peyronie’s disease come mainly from small cohorts and one interim randomised report. The Italian retrospective study recorded pain in 5.6% and haematoma in 2.8% of men. The Miami interim analysis and the French pilot study reported no adverse events. Rare risks include infection and bleeding, as with any injection. However, long-term safety data beyond six months remain scarce.
Costs and Access
Prices for a P shot London session typically range from £900 to £1,500, depending on the clinic. Study protocols used three to six injections. Therefore, a full course can cost several thousand pounds. Finally, men should request a written total cost before treatment.
Choosing a Qualified Provider
Peyronie’s disease needs accurate diagnosis before any injection. First, men should verify practitioner registration on the General Medical Council (GMC) register. In addition, clinics in England should hold Care Quality Commission (CQC) registration. Clinics that advertise a P shot London service differ in training, equipment and protocols. Written information should state clearly that PRP for Peyronie’s remains experimental.
Questions to Raise at Consultation
Men can raise the following questions before agreeing to treatment:
- Which protocol applies, and which published study supports it?
- How will the clinic measure curvature before and after treatment?
- What is the total cost, including follow-up?
- What happens if curvature does not change?
Clinic and Practitioner Background
Pshots clinic UK operates a Harley Street practice in Marylebone under Dr Syed Nadeem Abbas (MBBS, MRCSEd, MRCGP). The lead clinician also holds an MSc in Aesthetic Plastic Surgery with Distinction from Queen Mary University of London. Postgraduate training took place at Cambridge, Oxford and the Royal London Hospital. Overall, the same checks apply to every provider.
Frequently Asked Questions
Treatment and Evidence
Does the P-Shot for Peyronie’s disease straighten the penis?
No study shows complete straightening. Cohort studies report average curvature reductions of roughly 6° to 17°. Individual results vary, and randomised evidence remains limited.
Can PRP dissolve Peyronie’s plaque?
Some studies report small reductions in plaque size, consistent with limited PRP tissue repair effects. One Italian cohort recorded a fall from 11.1 mm to 8.2 mm. However, the studies reviewed here did not show complete plaque resolution.
Does PRP improve erectile function in Peyronie’s disease?
Findings vary. In the Italian retrospective study, a 1.1-point erectile function score gain lacked statistical significance. In the Moroccan cohort, 55.5% of men reported easier intercourse.
Does PRP work better than traction or surgery?
The studies reviewed here contain no head-to-head comparisons. Surgery remains the most established route for stable, severe curvature. PRP remains experimental.
Does PRP suit acute or chronic Peyronie’s disease?
The three larger cohorts enrolled men with stable disease. Evidence for the acute phase remains limited. A urologist can stage the disease using history, examination and ultrasound.
Safety and Practical Questions
How many PRP sessions do studies use?
Protocols ranged from three injections, one to two weeks apart, to 6.1 injections on average in the Moroccan cohort.
What side effects follow PRP injection?
Studies report mild, transient pain and occasional haematoma. Some trials recorded no adverse events.
Should a GP appointment come first?
Yes. The NHS advises seeking help for a pronounced curve or painful erections. A GP can examine the penis, arrange an ultrasound and discuss referral.
Key Takeaways
PRP for Peyronie’s holds an uncertain place in penile curvature care. Early studies report modest gains in curvature, plaque size and pain, alongside a mild safety profile. However, most studies lack control groups, and major guidelines classify PRP as experimental. Informed consent therefore means understanding both the promise and the gaps.
Men considering the P-Shot for Peyronie’s disease should first secure a confirmed diagnosis, disease staging and objective curvature measurement. In addition, a urology opinion helps compare surgery, traction and other options. Written protocols, session numbers and realistic outcomes deserve discussion before any injection. This article informs and does not replace individual medical advice.
If evidence for a treatment stays modest, how much uncertainty is acceptable when the decision affects intimacy and confidence?
Read more:
P-Shot for Sensitivity vs ED: Does It Work Differently?
P-Shot Near Me: How to Find a Qualified Clinic in the UK
Dr Syed Nadeem Abbas, MBBS, MRCSEd, MSc Aesthetic Plastic Surgery (Distinction) Medical Director, Pshot Clinic | CQC Regulated | Monday to Saturday 10:00–18:00 +44 7955 836986